Lucknow: In a landmark study, scientists from the University of Lucknow have scientifically validated the age-old wisdom that food can indeed be medicine. The research, led by Vikas Gautam under the mentorship of Prof. A. M. Saxena, explored five edible plants of the Cucurbitaceae family-Momordica charantia var. muricata (wild bitter gourd), Trichosanthes cucumerina (snake gourd), Luffa acutangula (ridge gourd), Cucumis sativus (cucumber), and Cucurbita pepo (pumpkin).
This comprehensive screening of antidiabetic activity, published in Cureus Journal (Springer Nature, 2025), was conducted through a novel four-In-vivo model covering fasted, fed, glucose-loaded, and diabetic rat models. The approach, jointly designed with endocrinologist Dr. Ashutosh Ranjan, ensures rapid evaluation of glucose-lowering potential in a shorter timeframe compared to conventional studies.
Among all plants tested, Momordica charantia var. muricata stood out by reducing blood glucose levels by nearly 31% in diabetic models, while Luffa acutngula and Cucumis sativus also showed notable glucose regulation. The study involved collaborative expertise from Prof Syed Shabihe Raza Baqri, who contributed to pharmacological and analytical design, and Dr Kumar Gaurav Bajpai, whose histological insight strengthened the validation process.
“This is more than just plant research, it’s about transforming everyday vegetables into therapeutic options,” said Vikas Gautam. “Our findings support safe, low-cost, food-based interventions that could relieve millions from the economic burden of diabetes.”
The study’s success emphasizes India’s traditional knowledge systems blended with scientific innovation, paving the way for eco-friendly, affordable, and accessible diabetes management strategies for the general public.
